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Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation
The endoplasmic reticulum (ER) mediates the folding, maturation, and deployment of the secretory proteome. Proteins that fail to achieve their native conformation are retained in the ER and targeted for clearance by ER-associated degradation (ERAD), a sophisticated process that mediates the ubiquiti...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5231896/ https://www.ncbi.nlm.nih.gov/pubmed/27881664 http://dx.doi.org/10.1091/mbc.E16-07-0483 |