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TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence
Human telomerase reverse transcriptase (hTERT) plays a central role in telomere lengthening for continuous cell proliferation, but it remains unclear how extracellular cues regulate telomerase lengthening of telomeres. Here we report that the cytokine bone morphogenetic protein-7 (BMP7) induces the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Higher Education Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233610/ https://www.ncbi.nlm.nih.gov/pubmed/27696331 http://dx.doi.org/10.1007/s13238-016-0322-1 |