TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence

Human telomerase reverse transcriptase (hTERT) plays a central role in telomere lengthening for continuous cell proliferation, but it remains unclear how extracellular cues regulate telomerase lengthening of telomeres. Here we report that the cytokine bone morphogenetic protein-7 (BMP7) induces the...

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Detalles Bibliográficos
Autores principales: Cassar, Lucy, Nicholls, Craig, Pinto, Alex R., Chen, Ruping, Wang, Lihui, Li, He, Liu, Jun-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233610/
https://www.ncbi.nlm.nih.gov/pubmed/27696331
http://dx.doi.org/10.1007/s13238-016-0322-1

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