Perturbed CD8(+) T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals

HIV-specific CD8(+) T cells demonstrate an exhausted phenotype associated with increased expression of inhibitory receptors, decreased functional capacity, and a skewed transcriptional profile, which are only partially restored by antiretroviral treatment (ART). Expression levels of the inhibitory r...

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Detalles Bibliográficos
Autores principales: Tauriainen, Johanna, Scharf, Lydia, Frederiksen, Juliet, Naji, Ali, Ljunggren, Hans-Gustaf, Sönnerborg, Anders, Lund, Ole, Reyes-Terán, Gustavo, Hecht, Frederick M., Deeks, Steven G., Betts, Michael R., Buggert, Marcus, Karlsson, Annika C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233961/
https://www.ncbi.nlm.nih.gov/pubmed/28084312
http://dx.doi.org/10.1038/srep40354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233961/
https://www.ncbi.nlm.nih.gov/pubmed/28084312
http://dx.doi.org/10.1038/srep40354

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