DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function

Parkinson’s disease is a neurodegenerative disorder characterized by the death of dopaminergic neurons and by accumulation of alpha-synuclein (aS) aggregates in the surviving neurons. The dopamine catabolite 3,4-dihydroxyphenylacetaldehyde (DOPAL) is a highly reactive and toxic molecule that leads t...

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Detalles Bibliográficos
Autores principales: Plotegher, N., Berti, G., Ferrari, E., Tessari, I., Zanetti, M., Lunelli, L., Greggio, E., Bisaglia, M., Veronesi, M., Girotto, S., Dalla Serra, M., Perego, C., Casella, L., Bubacco, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233976/
https://www.ncbi.nlm.nih.gov/pubmed/28084443
http://dx.doi.org/10.1038/srep40699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233976/
https://www.ncbi.nlm.nih.gov/pubmed/28084443
http://dx.doi.org/10.1038/srep40699

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