Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent immunodominant response overlapping the 2F5 binding motif

The HIV-1 gp41 Membrane Proximal External Region (MPER) is recognized by broadly neutralizing antibodies and represents a promising vaccine target. However, MPER immunogenicity and antibody activity are influenced by membrane lipids. To evaluate lipid modulation of MPER immunogenicity, we generated...

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Detalles Bibliográficos
Autores principales: Molinos-Albert, Luis M., Bilbao, Eneritz, Agulló, Luis, Marfil, Silvia, García, Elisabet, Concepción, Maria Luisa Rodríguez de la, Izquierdo-Useros, Nuria, Vilaplana, Cristina, Nieto-Garai, Jon A., Contreras, F.-Xabier, Floor, Martin, Cardona, Pere J., Martinez-Picado, Javier, Clotet, Bonaventura, Villà-Freixa, Jordi, Lorizate, Maier, Carrillo, Jorge, Blanco, Julià
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234007/
https://www.ncbi.nlm.nih.gov/pubmed/28084464
http://dx.doi.org/10.1038/srep40800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234007/
https://www.ncbi.nlm.nih.gov/pubmed/28084464
http://dx.doi.org/10.1038/srep40800

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