Rare Synaptogenesis-Impairing Mutations in SLITRK5 Are Associated with Obsessive Compulsive Disorder

Obsessive compulsive disorder (OCD) is substantially heritable, but few molecular genetic risk factors have been identified. Knockout mice lacking SLIT and NTRK-Like Family, Member 5 (SLITRK5) display OCD-like phenotypes including serotonin reuptake inhibitor-sensitive pathologic grooming, and corti...

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Detalles Bibliográficos
Autores principales: Song, Minseok, Mathews, Carol A., Stewart, S. Evelyn, Shmelkov, Sergey V., Mezey, Jason G., Rodriguez-Flores, Juan L., Rasmussen, Steven A., Britton, Jennifer C., Oh, Yong-Seok, Walkup, John T., Lee, Francis S., Glatt, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234816/
https://www.ncbi.nlm.nih.gov/pubmed/28085938
http://dx.doi.org/10.1371/journal.pone.0169994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234816/
https://www.ncbi.nlm.nih.gov/pubmed/28085938
http://dx.doi.org/10.1371/journal.pone.0169994

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