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Low-affinity CD4+ T cells are major responders in the primary immune response

A robust primary immune response has been correlated with the precursor number of antigen-specific T cells, as identified using peptide MHCII tetramers. However, these tetramers identify only the highest-affinity T cells. Here we show the entire CD4+ T-cell repertoire, inclusive of low-affinity T ce...

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Detalles Bibliográficos
Autores principales: Martinez, Ryan J., Andargachew, Rakieb, Martinez, Hunter A., Evavold, Brian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234832/
https://www.ncbi.nlm.nih.gov/pubmed/27976744
http://dx.doi.org/10.1038/ncomms13848