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Glucocorticoid Insensitivity in Virally Infected Airway Epithelial Cells Is Dependent on Transforming Growth Factor-β Activity

Asthma and chronic obstructive pulmonary disease (COPD) exacerbations are commonly associated with respiratory syncytial virus (RSV), rhinovirus (RV) and influenza A virus (IAV) infection. The ensuing airway inflammation is resistant to the anti-inflammatory actions of glucocorticoids (GCs). Viral i...

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Detalles Bibliográficos
Autores principales: Xia, Yuxiu C., Radwan, Asmaa, Keenan, Christine R., Langenbach, Shenna Y., Li, Meina, Radojicic, Danica, Londrigan, Sarah L., Gualano, Rosa C., Stewart, Alastair G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5234851/
https://www.ncbi.nlm.nih.gov/pubmed/28046097
http://dx.doi.org/10.1371/journal.ppat.1006138