Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons

Neurons face unique challenges of transporting nascent autophagic vacuoles (AVs) from distal axons toward the soma, where mature lysosomes are mainly located. Autophagy defects have been linked to Alzheimer’s disease (AD). However, the mechanisms underlying altered autophagy remain unknown. Here, we...

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Detalles Bibliográficos
Autores principales: Tammineni, Prasad, Ye, Xuan, Feng, Tuancheng, Aikal, Daniyal, Cai, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235353/
https://www.ncbi.nlm.nih.gov/pubmed/28085665
http://dx.doi.org/10.7554/eLife.21776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5235353/
https://www.ncbi.nlm.nih.gov/pubmed/28085665
http://dx.doi.org/10.7554/eLife.21776

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