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Delta-like 4/Notch signaling promotes Apc(Min/+) tumor initiation through angiogenic and non-angiogenic related mechanisms
BACKGROUND: Delta like 4 (Dll4)/Notch signaling is a key regulator of tumor angiogenesis. Additionally, the role of Dll4 has been studied on tumor stem cells. However, as these cells are implicated in tumor angiogenesis, it is conceivable that the effect of Dll4 on these cells may be a consequence o...
Autores principales: | Badenes, Marina, Trindade, Alexandre, Pissarra, Hugo, Lopes-da-Costa, Luís, Duarte, António |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237288/ https://www.ncbi.nlm.nih.gov/pubmed/28086833 http://dx.doi.org/10.1186/s12885-016-3036-0 |
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