Microhomology-mediated end joining: new players join the team

DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage in cells arising from endogenous and exogenous attacks on the genomic DNA. Timely and properly repair of DSBs is important for genomic integrity and survival. MMEJ is an error-prone repair mechanism for DSBs, which relies on...

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Detalles Bibliográficos
Autores principales: Wang, Hailong, Xu, Xingzhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237343/
https://www.ncbi.nlm.nih.gov/pubmed/28101326
http://dx.doi.org/10.1186/s13578-017-0136-8
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author Wang, Hailong
Xu, Xingzhi
author_facet Wang, Hailong
Xu, Xingzhi
author_sort Wang, Hailong
collection PubMed
description DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage in cells arising from endogenous and exogenous attacks on the genomic DNA. Timely and properly repair of DSBs is important for genomic integrity and survival. MMEJ is an error-prone repair mechanism for DSBs, which relies on exposed microhomologous sequence flanking broken junction to fix DSBs in a Ku- and ligase IV-independent manner. Recently, significant progress has been made in MMEJ mechanism study. In this review, we will summarize its biochemical activities of several newly identified MMEJ factors and their biological significance.
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spelling pubmed-52373432017-01-18 Microhomology-mediated end joining: new players join the team Wang, Hailong Xu, Xingzhi Cell Biosci Review DNA double-strand breaks (DSBs) are the most deleterious type of DNA damage in cells arising from endogenous and exogenous attacks on the genomic DNA. Timely and properly repair of DSBs is important for genomic integrity and survival. MMEJ is an error-prone repair mechanism for DSBs, which relies on exposed microhomologous sequence flanking broken junction to fix DSBs in a Ku- and ligase IV-independent manner. Recently, significant progress has been made in MMEJ mechanism study. In this review, we will summarize its biochemical activities of several newly identified MMEJ factors and their biological significance. BioMed Central 2017-01-13 /pmc/articles/PMC5237343/ /pubmed/28101326 http://dx.doi.org/10.1186/s13578-017-0136-8 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Wang, Hailong
Xu, Xingzhi
Microhomology-mediated end joining: new players join the team
title Microhomology-mediated end joining: new players join the team
title_full Microhomology-mediated end joining: new players join the team
title_fullStr Microhomology-mediated end joining: new players join the team
title_full_unstemmed Microhomology-mediated end joining: new players join the team
title_short Microhomology-mediated end joining: new players join the team
title_sort microhomology-mediated end joining: new players join the team
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237343/
https://www.ncbi.nlm.nih.gov/pubmed/28101326
http://dx.doi.org/10.1186/s13578-017-0136-8
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