Iron Deposition Leads to Neuronal α-Synuclein Pathology by Inducing Autophagy Dysfunction

Growing evidence has indicated that iron deposition in the substantia nigra plays an important role in Parkinson’s disease (PD). However, the underlying mechanism is still elusive. Using primary dopaminergic neurons and SH-SY5Y cells cultured in vitro, we observed that iron loading increased α-synuc...

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Detalles Bibliográficos
Autores principales: Wan, Wenbin, Jin, Lirong, Wang, Zigao, Wang, Lingyan, Fei, Guoqiang, Ye, Fanlong, Pan, Xiaoli, Wang, Changpeng, Zhong, Chunjiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237641/
https://www.ncbi.nlm.nih.gov/pubmed/28138322
http://dx.doi.org/10.3389/fneur.2017.00001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237641/
https://www.ncbi.nlm.nih.gov/pubmed/28138322
http://dx.doi.org/10.3389/fneur.2017.00001

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