Use of a cocktail probe to assess potential drug interactions with cytochrome P450 after administration of belatacept, a costimulatory immunomodulator

AIM: This open‐label study investigated the effect of belatacept on cytokine levels and on the pharmacokinetics of caffeine, losartan, omeprazole, dextromethorphan and midazolam, as CYP probe substrates after oral administration of the Inje cocktail in healthy volunteers. METHODS: Twenty‐two evaluab...

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Detalles Bibliográficos
Autores principales: Williams, Daphne, Tao, Xiaolu, Zhu, Lili, Stonier, Michele, Lutz, Justin D., Masson, Eric, Zhang, Sean, Ganguly, Bishu, Tzogas, Zoe, Lubin, Susan, Murthy, Bindu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Drug Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237687/
https://www.ncbi.nlm.nih.gov/pubmed/27552251
http://dx.doi.org/10.1111/bcp.13097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237687/
https://www.ncbi.nlm.nih.gov/pubmed/27552251
http://dx.doi.org/10.1111/bcp.13097

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