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Synthesis of hydroxycinnamic acid derivatives as mitochondria-targeted antioxidants and cytotoxic agents

In order to develop agents with superior chemopreventive and chemotherapeutic properties against hepatocellular carcinomas, mitochondria-targeted hydroxycinnamic acids (MitoHCAs) were synthesized by conjugation with a triphenylphosphonium cation. These synthetic compounds were evaluated for their an...

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Detalles Bibliográficos
Autores principales: Li, Jiyu, He, Dian, Wang, Baitao, Zhang, Ling, Li, Kun, Xie, Qinjian, Zheng, Lifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237706/
https://www.ncbi.nlm.nih.gov/pubmed/28119815
http://dx.doi.org/10.1016/j.apsb.2016.05.002