Association of erythrocyte methotrexate-polyglutamate levels with the efficacy and hepatotoxicity of methotrexate in patients with rheumatoid arthritis: a 76-week prospective study

OBJECTIVE: To assess the utility of erythrocyte methotrexate-polyglutamate (MTX-PG) concentrations in determining the safety and efficacy of MTX in patients with rheumatoid arthritis (RA). METHODS: 79 MTX-naïve patients with RA were enrolled in this prospective 76-week cohort study. MTX was initiate...

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Detalles Bibliográficos
Autores principales: Takahashi, Chihiro, Kaneko, Yuko, Okano, Yutaka, Taguchi, Hiroaki, Oshima, Hisaji, Izumi, Keisuke, Yamaoka, Kunihiro, Takeuchi, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2017
Materias:
Rheumatoid Arthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237762/
https://www.ncbi.nlm.nih.gov/pubmed/28123781
http://dx.doi.org/10.1136/rmdopen-2016-000363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237762/
https://www.ncbi.nlm.nih.gov/pubmed/28123781
http://dx.doi.org/10.1136/rmdopen-2016-000363

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