Pirfenidone controls the feedback loop of the AT1R/p38 MAPK/renin-angiotensin system axis by regulating liver X receptor-α in myocardial infarction-induced cardiac fibrosis

Pirfenidone (PFD), an anti-fibrotic small molecule drug, is used to treat fibrotic diseases, but its effects on myocardial infarction (MI)-induced cardiac fibrosis are unknown. The aim of this study was to determine the effects of PFD on MI-induced cardiac fibrosis and the possible underlying mechan...

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Detalles Bibliográficos
Autores principales: Li, Chunmei, Han, Rui, Kang, Le, Wang, Jianping, Gao, Yonglin, Li, Yanshen, He, Jie, Tian, Jingwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238375/
https://www.ncbi.nlm.nih.gov/pubmed/28091615
http://dx.doi.org/10.1038/srep40523

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238375/
https://www.ncbi.nlm.nih.gov/pubmed/28091615
http://dx.doi.org/10.1038/srep40523

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