Chemical Isotope Labeling LC-MS for Monitoring Disease Progression and Treatment in Animal Models: Plasma Metabolomics Study of Osteoarthritis Rat Model

We report a chemical isotope labeling (CIL) liquid chromatography mass spectrometry (LC-MS) method generally applicable for tracking metabolomic changes from samples collected in an animal model for studying disease development and treatment. A rat model of surgically induced osteoarthritis (OA) was...

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Detalles Bibliográficos
Autores principales: Chen, Deying, Su, Xiaoling, Wang, Nan, Li, Yunong, Yin, Hua, Li, Liang, Li, Lanjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238386/
https://www.ncbi.nlm.nih.gov/pubmed/28091618
http://dx.doi.org/10.1038/srep40543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238386/
https://www.ncbi.nlm.nih.gov/pubmed/28091618
http://dx.doi.org/10.1038/srep40543

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