Origin of anti-tumor activity of the cysteine-containing GO peptides and further optimization of their cytotoxic properties

Antitumor GO peptides have been designed as dimerization inhibitors of prominent oncoprotein mucin 1. In this study we demonstrate that activity of GO peptides is independent of the level of cellular expression of mucin 1. Furthermore, these peptides prove to be broadly cytotoxic, causing cell death...

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Detalles Bibliográficos
Autores principales: Tyuryaeva, Irina I., Lyublinskaya, Olga G., Podkorytov, Ivan S., Skrynnikov, Nikolai R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238392/
https://www.ncbi.nlm.nih.gov/pubmed/28091523
http://dx.doi.org/10.1038/srep40217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238392/
https://www.ncbi.nlm.nih.gov/pubmed/28091523
http://dx.doi.org/10.1038/srep40217

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