Cargando…
Origin of anti-tumor activity of the cysteine-containing GO peptides and further optimization of their cytotoxic properties
Antitumor GO peptides have been designed as dimerization inhibitors of prominent oncoprotein mucin 1. In this study we demonstrate that activity of GO peptides is independent of the level of cellular expression of mucin 1. Furthermore, these peptides prove to be broadly cytotoxic, causing cell death...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238392/ https://www.ncbi.nlm.nih.gov/pubmed/28091523 http://dx.doi.org/10.1038/srep40217 |