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A disrupted transsulphuration pathway results in accumulation of redox metabolites and induction of gametocytogenesis in malaria

Intra-erythrocytic growth of malaria parasite is known to induce redox stress. In addition to haem degradation which generates reactive oxygen species (ROS), the parasite is also thought to efflux redox active homocysteine. To understand the basis underlying accumulation of homocysteine, we have exa...

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Detalles Bibliográficos
Autores principales: Beri, Divya, Balan, Balu, Chaubey, Shweta, Subramaniam, Suraj, Surendra, Bachu, Tatu, Utpal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238400/
https://www.ncbi.nlm.nih.gov/pubmed/28091526
http://dx.doi.org/10.1038/srep40213