Cargando…

Apelin receptor homodimer-oligomers revealed by single-molecule imaging and novel G protein-dependent signaling

The apelin receptor (APJ) belongs to family A of the G protein-coupled receptors (GPCRs) and is a potential pharmacotherapeutic target for heart failure, hypertension, and other cardiovascular diseases. There is evidence APJ heterodimerizes with other GPCRs; however, the existence of APJ homodimers...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cai, Xin, Bai, Bo, Zhang, Rumin, Wang, Chunmei, Chen, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238433/ https://www.ncbi.nlm.nih.gov/pubmed/28091541 http://dx.doi.org/10.1038/srep40335

Ejemplares similares

The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles
por: Jiang, Yunlu, et al.
Publicado: (2021)

Individual phosphorylation sites at the C-terminus of the apelin receptor play different roles in signal transduction
por: Chen, Jing, et al.
Publicado: (2020)

The Role of Apelin/Apelin Receptor in Energy Metabolism and Water Homeostasis: A Comprehensive Narrative Review
por: Hu, Gonghui, et al.
Publicado: (2021)

A covalent homodimer probing early oligomers along amyloid aggregation
por: Halabelian, Levon, et al.
Publicado: (2015)

Temporal Expression of Apelin/Apelin Receptor in Ischemic Stroke and its Therapeutic Potential
por: Wu, Yili, et al.
Publicado: (2017)

Cardiac action of the first G protein biased small molecule apelin agonist
por: Read, Cai, et al.
Publicado: (2016)

Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK(1/2) and cell proliferation via Gαq-mediated mechanism
por: Bai, Bo, et al.
Publicado: (2014)

Single Molecule Analysis of Functionally Asymmetric G Protein-coupled Receptor (GPCR) Oligomers Reveals Diverse Spatial and Structural Assemblies
por: Jonas, Kim C., et al.
Publicado: (2015)

Single-Molecule 3D Images of “Hole-Hole” IgG1 Homodimers by Individual-Particle Electron Tomography
por: Lei, Dongsheng, et al.
Publicado: (2019)

On Methods for the Measurement of the Apelin Receptor Ligand Apelin
por: Janssens, Peter, et al.
Publicado: (2022)

Apelin and apelin receptor expression in renal cell carcinoma
por: Tolkach, Yuri, et al.
Publicado: (2019)

Single Molecule Characterization of Amyloid Oligomers
por: Yang, Jie, et al.
Publicado: (2021)

Triple-color single-molecule imaging for analysis of the role of receptor oligomers in signal transduction
por: Yoshimura, Hideaki
Publicado: (2022)

Headgroup-Dependent Membrane Catalysis of Apelin−Receptor Interactions Is Likely
por: Langelaan, David N., et al.
Publicado: (2009)

Disruption of 5-hydroxytryptamine 1A receptor and orexin receptor 1 heterodimer formation affects novel G protein-dependent signaling pathways and has antidepressant effects in vivo
por: Zhang, Rumin, et al.
Publicado: (2022)

Crystal structure of endonuclease G in complex with DNA reveals how it nonspecifically degrades DNA as a homodimer
por: Lin, Jason L. J., et al.
Publicado: (2016)

Classification and clustering of RNA crosslink-ligation data reveal complex structures and homodimers
por: Zhang, Minjie, et al.
Publicado: (2022)

Evaluation of Apelin and Apelin Receptor Level in the Primary Tumor and Serum of Colorectal Cancer Patients
por: Podgórska, Marta, et al.
Publicado: (2019)

Apelin and Apelin Receptor in Follicular Granulosa Cells of Buffalo Ovaries: Expression and Regulation of Steroidogenesis
por: Shokrollahi, Borhan, et al.
Publicado: (2022)

Targeting the elabela/apelin-apelin receptor axis as a novel therapeutic approach for hypertension
por: Song, Jiawei, et al.
Publicado: (2022)

Comparative Study of Elabela and Apelin on Apelin Receptor Activation Through β-Arrestin Recruitment
por: Zhang, Hong, et al.
Publicado: (2022)

Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides that improve diet induced obesity are G protein biased ligands at the apelin receptor
por: Nyimanu, Duuamene, et al.
Publicado: (2019)

In vivo modulation of endothelial polarization by Apelin receptor signalling
por: Kwon, Hyouk-Bum, et al.
Publicado: (2016)

Assaying Homodimers of NF-κB in Live Single Cells
por: Martin, Erik W., et al.
Publicado: (2019)

Locked nucleic acid oligomers as handles for single molecule manipulation
por: Berezney, John P., et al.
Publicado: (2014)

Detection of Single Molecules Using Stochastic Resonance of Bistable Oligomers
por: Markina, Anastasia, et al.
Publicado: (2020)

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity
por: Abdiche, Yasmina Noubia, et al.
Publicado: (2015)

Ligand Binding Dynamics for Pre-dimerised G Protein-Coupled Receptor Homodimers: Linear Models and Analytical Solutions
por: White, Carla, et al.
Publicado: (2018)

The apelin-apelin receptor signaling pathway in fibroblasts is involved in tumor growth via p53 expression of cancer cells
por: Saiki, Hirotsugu, et al.
Publicado: (2023)

Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger
por: Liu, Qianying, et al.
Publicado: (2023)

Load-dependent effects of apelin on murine cardiomyocytes
por: Peyronnet, Rémi, et al.
Publicado: (2017)

Apelin Controls Angiogenesis-Dependent Glioblastoma Growth
por: Frisch, Anne, et al.
Publicado: (2020)

Effect of apelin on cardiac contractility in acute reno-vascular hypertension: The role of apelin receptor and kappa opioid receptor heterodimerization
por: Yeganeh-Hajahmadi, Mahboobeh, et al.
Publicado: (2018)

Characterization of the Apelin/Elabela Receptors (APLNR) in Chickens, Turtles, and Zebrafish: Identification of a Novel Apelin-Specific Receptor in Teleosts
por: Zhang, Jiannan, et al.
Publicado: (2018)

Elabela-Apelin Receptor Signaling Pathway is Functional in Mammalian Systems
por: Wang, Zhi, et al.
Publicado: (2015)

Making Structural Sense of Dimerization Interfaces of Delta Opioid Receptor Homodimers
por: Johnston, Jennifer M., et al.
Publicado: (2011)

Association of apelin and apelin receptor with the risk of coronary artery disease: a meta-analysis of observational studies
por: Chen, Tianbao, et al.
Publicado: (2017)

Association of Apelin and Apelin Receptor Polymorphisms With the Risk of Comorbid Depression and Anxiety in Coronary Heart Disease Patients
por: Wang, Ying, et al.
Publicado: (2020)

Types of interfaces for homodimer folding and binding
por: Karthikraja, Velmurugan, et al.
Publicado: (2009)

Agonist-induced internalization and desensitization of the apelin receptor
por: Pope, George R., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mofjf6el3qbq2mebbfonbloffh