Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion

Recombinant protein production coopts the host cell machinery to provide high protein yields of industrial enzymes or biotherapeutics. However, since protein translation is energetically expensive and tightly controlled, it is unclear if highly expressed recombinant genes are translated as efficient...

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Detalles Bibliográficos
Autores principales: Kallehauge, Thomas Beuchert, Li, Shangzhong, Pedersen, Lasse Ebdrup, Ha, Tae Kwang, Ley, Daniel, Andersen, Mikael Rørdam, Kildegaard, Helene Faustrup, Lee, Gyun Min, Lewis, Nathan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238448/
https://www.ncbi.nlm.nih.gov/pubmed/28091612
http://dx.doi.org/10.1038/srep40388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238448/
https://www.ncbi.nlm.nih.gov/pubmed/28091612
http://dx.doi.org/10.1038/srep40388

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