Combination of Everolimus with Sorafenib for Solid Renal Tumors in Tsc2(+/−) Mice Is Superior to Everolimus Alone()

Tuberous sclerosis (TSC) is an inherited tumor syndrome caused by mutations in TSC1 or TSC2 that lead to aberrant activation of mTOR and development of tumors in multiple organs including the kidneys. The mTOR inhibitors rapamycin and everolimus (rapalogs) have demonstrated clinical efficacy in trea...

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Detalles Bibliográficos
Autores principales: Yang, Jian, Samsel, Paulina A., Narov, Kalin, Jones, Ashley, Gallacher, Daniel, Gallacher, John, Sampson, Julian R., Shen, Ming Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2017
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238457/
https://www.ncbi.nlm.nih.gov/pubmed/28092822
http://dx.doi.org/10.1016/j.neo.2016.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238457/
https://www.ncbi.nlm.nih.gov/pubmed/28092822
http://dx.doi.org/10.1016/j.neo.2016.12.008

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