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Facile synthesis of a 3-deazaadenosine phosphoramidite for RNA solid-phase synthesis

Access to 3-deazaadenosine (c(3)A) building blocks for RNA solid-phase synthesis represents a severe bottleneck in modern RNA research, in particular for atomic mutagenesis experiments to explore mechanistic aspects of ribozyme catalysis. Here, we report the 5-step synthesis of a c(3)A phosphoramidi...

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Detalles Bibliográficos
Autores principales:	Mairhofer, Elisabeth, Fuchs, Elisabeth, Micura, Ronald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2016
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238537/ https://www.ncbi.nlm.nih.gov/pubmed/28144324 http://dx.doi.org/10.3762/bjoc.12.250

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