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Development of a continuous process for α-thio-β-chloroacrylamide synthesis with enhanced control of a cascade transformation
A continuous process strategy has been developed for the preparation of α-thio-β-chloroacrylamides, a class of highly versatile synthetic intermediates. Flow platforms to generate the α-chloroamide and α-thioamide precursors were successfully adopted, progressing from the previously employed batch c...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238589/ https://www.ncbi.nlm.nih.gov/pubmed/28144320 http://dx.doi.org/10.3762/bjoc.12.246 |