Synthesis of spiro[isoindole-1,5’-isoxazolidin]-3(2H)-ones as potential inhibitors of the MDM2-p53 interaction

A series of spiro[isoindole-1,5-isoxazolidin]-3(2H)-ones has been synthesized by 1,3-dipolar cycloaddition of N-benzylnitrone with isoindolin-3-methylene-1-ones. The regio- and stereoselectivity of the process have been rationalized by computational methods. The obtained compounds show cytotoxic pro...

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Detalles Bibliográficos
Autores principales: Giofrè, Salvatore V, Cirmi, Santa, Mancuso, Raffaella, Nicolò, Francesco, Lanza, Giuseppe, Legnani, Laura, Campisi, Agata, Chiacchio, Maria A, Navarra, Michele, Gabriele, Bartolo, Romeo, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2016
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238597/
https://www.ncbi.nlm.nih.gov/pubmed/28144352
http://dx.doi.org/10.3762/bjoc.12.278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238597/
https://www.ncbi.nlm.nih.gov/pubmed/28144352
http://dx.doi.org/10.3762/bjoc.12.278

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