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Topoisomerase I inhibition leads to length-dependent gene expression changes in human primary astrocytes
Topoisomerase I is required for the proper expression of long genes (> 100 kb) in mouse and human cortical neurons, including many candidate genes for autism spectrum disorder (ASD) [1]. Given the important role of astrocytes in brain development [2], we investigated whether long genes, including...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238604/ https://www.ncbi.nlm.nih.gov/pubmed/28119819 http://dx.doi.org/10.1016/j.gdata.2016.12.005 |