Cargando…

Enzymatic synthesis and phosphorolysis of 4(2)-thioxo- and 6(5)-azapyrimidine nucleosides by E. coli nucleoside phosphorylases

The trans-2-deoxyribosylation of 4-thiouracil ((4S)Ura) and 2-thiouracil ((2S)Ura), as well as 6-azauracil, 6-azathymine and 6-aza-2-thiothymine was studied using dG and E. coli purine nucleoside phosphorylase (PNP) for the in situ generation of 2-deoxy-α-D-ribofuranose-1-phosphate (dRib-1P) followe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stepchenko, Vladimir A, Miroshnikov, Anatoly I, Seela, Frank, Mikhailopulo, Igor A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2016
Materias:	Full Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238616/ https://www.ncbi.nlm.nih.gov/pubmed/28144328 http://dx.doi.org/10.3762/bjoc.12.254

Ejemplares similares

The chemoenzymatic synthesis of clofarabine and related 2′-deoxyfluoroarabinosyl nucleosides: the electronic and stereochemical factors determining substrate recognition by E. coli nucleoside phosphorylases
por: Fateev, Ilja V, et al.
Publicado: (2014)

Anion exchange resins in phosphate form as versatile carriers for the reactions catalyzed by nucleoside phosphorylases
por: Artsemyeva, Julia N, et al.
Publicado: (2020)

New Trends in Nucleoside Biotechnology
por: Mikhailopulo, I.A., et al.
Publicado: (2010)

Radical Dehalogenation and Purine Nucleoside Phosphorylase E. coli: How Does an Admixture of 2′,3′-Anhydroinosine Hinder 2-fluoro-cordycepin Synthesis
por: Kayushin, Alexey L., et al.
Publicado: (2021)

Sustainable Flow‐Synthesis of (Bulky) Nucleoside Drugs by a Novel and Highly Stable Nucleoside Phosphorylase Immobilized on Reusable Supports
por: Benítez‐Mateos, Ana I., et al.
Publicado: (2021)

Strained Conformations of Nucleosides in Active Sites of Nucleoside Phosphorylases
por: Il’icheva, Irina A., et al.
Publicado: (2020)

Kinetic Analysis of the Hydrolysis of Pentose‐1‐phosphates through Apparent Nucleoside Phosphorolysis Equilibrium Shifts
por: Kaspar, Felix, et al.
Publicado: (2020)

Enzymatic separation of epimeric 4-C-hydroxymethylated furanosugars: Synthesis of bicyclic nucleosides
por: Rana, Neha, et al.
Publicado: (2017)

Purine nucleoside phosphorylase is associated with centrioles and basal bodies
Publicado: (1981)

Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases
por: Chaikuad, Apirat, et al.
Publicado: (2009)

Efficient Synthesis of Purine Nucleoside Analogs by a New Trimeric Purine Nucleoside Phosphorylase from Aneurinibacillus migulanus AM007
por: Liu, Gaofei, et al.
Publicado: (2019)

Comparative Analysis of Enzymatic Transglycosylation Using E. coli Nucleoside Phosphorylases: A Synthetic Concept for the Preparation of Purine Modified 2′-Deoxyribonucleosides from Ribonucleosides
por: Drenichev, Mikhail S., et al.
Publicado: (2022)

Adenosine Deaminase, Nucleoside Phosphorylase and Xanthine Oxidase in Liver Tumours
por: Reid, E., et al.
Publicado: (1957)

Purine nucleoside phosphorylase deficiency in two unrelated Saudi patients
por: Alangari, Abdullah, et al.
Publicado: (2009)

General Principles for Yield Optimization of Nucleoside Phosphorylase‐Catalyzed Transglycosylations
por: Kaspar, Felix, et al.
Publicado: (2020)

Cellobiose phosphorylase from Caldicellulosiruptor bescii catalyzes reversible phosphorolysis via different kinetic mechanisms
por: Bai, Shaowei, et al.
Publicado: (2022)

Nucleoside Sensing
por: Fokkens, Michael, et al.
Publicado: (2006)

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors
por: Skácel, Jan, et al.
Publicado: (2023)

Synthesis of New 5′-Norcarbocyclic Aza/Deaza Purine Fleximers - Noncompetitive Inhibitors of E.coli Purine Nucleoside Phosphorylase
por: Khandazhinskaya, Anastasia, et al.
Publicado: (2022)

Enzymatic Synthesis of Highly Fluorescent 8-Azapurine Ribosides Using a Purine Nucleoside Phosphorylase Reverse Reaction: Variable Ribosylation Sites
por: Stachelska-Wierzchowska, Alicja, et al.
Publicado: (2013)

Optimized Biocatalytic Synthesis of 2‐Selenopyrimidine Nucleosides by Transglycosylation
por: Hellendahl, Katja F., et al.
Publicado: (2021)

Structural Determinants of the 5′-Methylthioinosine Specificity of Plasmodium Purine Nucleoside Phosphorylase
por: Donaldson, Teraya M., et al.
Publicado: (2014)

Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells
por: Kropotov, Andrey, et al.
Publicado: (2022)

8-Aminoinosine and 8-Aminohypoxanthine Inhibit Purine Nucleoside Phosphorylase and Exert Diuretic and Natriuretic Activity
por: Jackson, Edwin K., et al.
Publicado: (2022)

Nucleoside 2'-Deoxyribosyltransferase from Psychrophilic Bacterium Bacillus psychrosaccharolyticus — Preparation of an Immobilized Biocatalyst for the Enzymatic Synthesis of Therapeutic Nucleosides
por: Fresco-Taboada, Alba, et al.
Publicado: (2014)

Synthesis of some novel hydrazono acyclic nucleoside analogues
por: Soltani Rad, Mohammad N, et al.
Publicado: (2010)

Synthesis of ribavirin 2’-Me-C-nucleoside analogues
por: Cosson, Fanny, et al.
Publicado: (2017)

Antitumor effects of a dual-specific lentiviral vector carrying the Escherichia coli purine nucleoside phosphorylase gene
por: Wang, Xiaolong, et al.
Publicado: (2017)

Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient‐derived xenografts
por: Rab, Regina, et al.
Publicado: (2022)

Purine nucleoside phosphorylase from Schistosoma mansoni in complex with ribose-1-phosphate
por: D’Muniz Pereira, Humberto, et al.
Publicado: (2011)

Purine nucleoside phosphorylase inhibitors - an immunotherapy with novel mechanism of action for the treatment of melanoma
por: Bantia, Shanta
Publicado: (2015)

The Peculiar Case of the Hyper‐thermostable Pyrimidine Nucleoside Phosphorylase from Thermus thermophilus
por: Kaspar, Felix, et al.
Publicado: (2021)

Metabolites of Purine Nucleoside Phosphorylase (NP) in Serum Have the Potential to Delineate Pancreatic Adenocarcinoma
por: Vareed, Shaiju K., et al.
Publicado: (2011)

Purine nucleoside phosphorylase inhibition ameliorates age-associated lower urinary tract dysfunctions
por: Birder, Lori A., et al.
Publicado: (2020)

Synthesis of coumarin or ferrocene labeled nucleosides via Staudinger ligation
por: Kosiova, Ivana, et al.
Publicado: (2006)

Nucleoside macrocycles formed by intramolecular click reaction: efficient cyclization of pyrimidine nucleosides decorated with 5'-azido residues and 5-octadiynyl side chains
por: Liu, Jiang, et al.
Publicado: (2018)

Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase
por: Parker, W B, et al.
Publicado: (2011)

Multi-Enzymatic Cascades in the Synthesis of Modified Nucleosides: Comparison of the Thermophilic and Mesophilic Pathways
por: Fateev, Ilja V., et al.
Publicado: (2021)

Mitochondrial Basis for Immune Deficiency: Evidence from Purine Nucleoside Phosphorylase–Deficient Mice
por: Arpaia, Enrico, et al.
Publicado: (2000)

Synthesis of new p-tert-butylcalix[4]arene-based polyammonium triazolyl amphiphiles and their binding with nucleoside phosphates
por: Burilov, Vladimir A, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_fl6mj92qlvgvu95fdaifgcltg3