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Thioredoxin-dependent disulfide bond reduction is required for protamine eviction from sperm chromatin
Cysteine oxidation in protamines leads to their oligomerization and contributes to sperm chromatin compaction. Here we identify the Drosophila thioredoxin Deadhead (DHD) as the factor responsible for the reduction of intermolecular disulfide bonds in protamines and their eviction from sperm during f...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238724/ https://www.ncbi.nlm.nih.gov/pubmed/28031247 http://dx.doi.org/10.1101/gad.290916.116 |