SF3B1/Hsh155 HEAT motif mutations affect interaction with the spliceosomal ATPase Prp5, resulting in altered branch site selectivity in pre-mRNA splicing

Mutations in the U2 snRNP component SF3B1 are prominent in myelodysplastic syndromes (MDSs) and other cancers and have been shown recently to alter branch site (BS) or 3′ splice site selection in splicing. However, the molecular mechanism of altered splicing is not known. We show here that hsh155 mu...

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Detalles Bibliográficos
Autores principales: Tang, Qing, Rodriguez-Santiago, Susana, Wang, Jing, Pu, Jia, Yuste, Andrea, Gupta, Varun, Moldón, Alberto, Xu, Yong-Zhen, Query, Charles C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238730/
https://www.ncbi.nlm.nih.gov/pubmed/28087715
http://dx.doi.org/10.1101/gad.291872.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238730/
https://www.ncbi.nlm.nih.gov/pubmed/28087715
http://dx.doi.org/10.1101/gad.291872.116

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