Single-molecule FRET-Rosetta reveals RNA structural rearrangements during human telomerase catalysis

Maintenance of telomeres by telomerase permits continuous proliferation of rapidly dividing cells, including the majority of human cancers. Despite its direct biomedical significance, the architecture of the human telomerase complex remains unknown. Generating homogeneous telomerase samples has pres...

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Detalles Bibliográficos
Autores principales: Parks, Joseph W., Kappel, Kalli, Das, Rhiju, Stone, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238793/
https://www.ncbi.nlm.nih.gov/pubmed/28096444
http://dx.doi.org/10.1261/rna.058743.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238793/
https://www.ncbi.nlm.nih.gov/pubmed/28096444
http://dx.doi.org/10.1261/rna.058743.116

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