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Single-molecule FRET-Rosetta reveals RNA structural rearrangements during human telomerase catalysis
Maintenance of telomeres by telomerase permits continuous proliferation of rapidly dividing cells, including the majority of human cancers. Despite its direct biomedical significance, the architecture of the human telomerase complex remains unknown. Generating homogeneous telomerase samples has pres...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238793/ https://www.ncbi.nlm.nih.gov/pubmed/28096444 http://dx.doi.org/10.1261/rna.058743.116 |