Transcriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways

Besides degrading aberrant mRNAs that harbor a premature translation termination codon (PTC), nonsense-mediated mRNA decay (NMD) also targets many seemingly “normal” mRNAs that encode for full-length proteins. To identify a bona fide set of such endogenous NMD targets in human cells, we applied a me...

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Detalles Bibliográficos
Autores principales: Colombo, Martino, Karousis, Evangelos D., Bourquin, Joël, Bruggmann, Rémy, Mühlemann, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238794/
https://www.ncbi.nlm.nih.gov/pubmed/27864472
http://dx.doi.org/10.1261/rna.059055.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238794/
https://www.ncbi.nlm.nih.gov/pubmed/27864472
http://dx.doi.org/10.1261/rna.059055.116

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