Unraveling the stereochemical and dynamic aspects of the catalytic site of bacterial peptidyl-tRNA hydrolase

Bacterial peptidyl-tRNA hydrolase (Pth; EC 3.1.1.29) hydrolyzes the peptidyl-tRNAs accumulated in the cytoplasm and thereby prevents cell death by alleviating tRNA starvation. X-ray and NMR studies of Vibrio cholerae Pth (VcPth) and mutants of its key residues involved in catalysis show that the act...

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Detalles Bibliográficos
Autores principales: Kabra, Ashish, Shahid, Salman, Pal, Ravi Kant, Yadav, Rahul, Pulavarti, S.V.S. Rama Krishna, Jain, Anupam, Tripathi, Sarita, Arora, Ashish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238795/
https://www.ncbi.nlm.nih.gov/pubmed/28096445
http://dx.doi.org/10.1261/rna.057620.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238795/
https://www.ncbi.nlm.nih.gov/pubmed/28096445
http://dx.doi.org/10.1261/rna.057620.116

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