Deposition of insoluble elastin by pulmonary fibroblasts from patients with COPD is increased by treatment with versican siRNA

A reduced content of alveolar elastic fibers is a key feature of COPD lung. Despite continued elastogenic potential by alveolar fibroblasts in the lung affected by COPD, repair of elastic fibers does not take place, which is due to increased levels of the chondroitin sulfate proteoglycan versican th...

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Detalles Bibliográficos
Autores principales: Wu, Lian, Zhang, Jing, Qu, Jie Ming, Bai, Chun-xue, Merrilees, Mervyn J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238801/
https://www.ncbi.nlm.nih.gov/pubmed/28138236
http://dx.doi.org/10.2147/COPD.S116217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238801/
https://www.ncbi.nlm.nih.gov/pubmed/28138236
http://dx.doi.org/10.2147/COPD.S116217

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