Virtual screening, optimization, and identification of a novel specific PTP-MEG2 Inhibitor with potential therapy for T2DM

Megakaryocyte protein tyrosine phosphatase 2 (PTP-MEG2) is a tyrosine phosphatase expressed in megakaryocytic cells, and causes insulin sensitization when down regulated. Therefore, specific inhibitors of PTP-MEG2 are potential candidates for novel Type 2 Diabetes (T2DM)therapy. In this study, we di...

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Detalles Bibliográficos
Autores principales: Wang, Meiyan, Li, Xiaobo, Dong, Lei, Chen, Xiubo, Xu, Weiren, Wang, Runling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Gerotarget (Focus on Aging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239439/
https://www.ncbi.nlm.nih.gov/pubmed/27384997
http://dx.doi.org/10.18632/oncotarget.10341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239439/
https://www.ncbi.nlm.nih.gov/pubmed/27384997
http://dx.doi.org/10.18632/oncotarget.10341

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