P300 inhibition enhances gemcitabine-induced apoptosis of pancreatic cancer

The transcriptional cofactor p300 has histone acetyltransferase activity (HAT) and has been reported to participate in chromatin remodeling and DNA repair. We hypothesized that targeting p300 can enhance the cytotoxicity of gemcitabine, which induces pancreatic cancer cell apoptosis by damaging DNA....

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Detalles Bibliográficos
Autores principales: Ono, Hiroaki, Basson, Marc D., Ito, Hiromichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239476/
https://www.ncbi.nlm.nih.gov/pubmed/27322077
http://dx.doi.org/10.18632/oncotarget.10117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239476/
https://www.ncbi.nlm.nih.gov/pubmed/27322077
http://dx.doi.org/10.18632/oncotarget.10117

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