Loss of insulin-like growth factor II imprinting is a hallmark associated with enhanced chemo/radiotherapy resistance in cancer stem cells

Insulin-like growth factor II (IGF2) is maternally imprinted in most tissues, but the epigenetic regulation of the gene in cancer stem cells (CSCs) has not been defined. To study the epigenetic mechanisms underlying self-renewal, we isolated CSCs and non-CSCs from colon cancer (HT29, HRT18, HCT116),...

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Detalles Bibliográficos
Autores principales: Zhao, Xin, Liu, Xiaoliang, Wang, Guanjun, Wen, Xue, Zhang, Xiaoying, Hoffman, Andrew R., Li, Wei, Hu, Ji-Fan, Cui, Jiuwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239480/
https://www.ncbi.nlm.nih.gov/pubmed/27275535
http://dx.doi.org/10.18632/oncotarget.9784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239480/
https://www.ncbi.nlm.nih.gov/pubmed/27275535
http://dx.doi.org/10.18632/oncotarget.9784

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