Icariside II overcomes TRAIL resistance of melanoma cells through ROS-mediated downregulation of STAT3/cFLIP signaling

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising antitumor agent. However, many melanoma cells show weak responses to TRAIL. Here, we investigated whether Icariside II (IS), an active component of Herba Epimedii, could potentiate antitumor effects of TRAIL in melanoma c...

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Detalles Bibliográficos
Autores principales: Du, Juan, Wu, Jinfeng, Fu, Xiuqiong, Tse, Anfernee Kai-Wing, Li, Ting, Su, Tao, Yu, Zhi-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239546/
https://www.ncbi.nlm.nih.gov/pubmed/27418138
http://dx.doi.org/10.18632/oncotarget.10582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239546/
https://www.ncbi.nlm.nih.gov/pubmed/27418138
http://dx.doi.org/10.18632/oncotarget.10582

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