VPS34 regulates TSC1/TSC2 heterodimer to mediate RheB and mTORC1/S6K1 activation and cellular transformation

VPS34 is reported to activate S6K1 and is implicated in regulating cell growth, the mechanisms of which remain elusive. Here, we describe novel mechanisms by which VPS34 upregulates mTOR/S6K1 activity via downregulating TSC2 protein and activating RheB activity. Specifically, upregulation of VPS34 l...

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Detalles Bibliográficos
Autores principales: Mohan, Nishant, Shen, Yi, Dokmanovic, Milos, Endo, Yukinori, Hirsch, Dianne S., Wu, Wen Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239548/
https://www.ncbi.nlm.nih.gov/pubmed/27409169
http://dx.doi.org/10.18632/oncotarget.10469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239548/
https://www.ncbi.nlm.nih.gov/pubmed/27409169
http://dx.doi.org/10.18632/oncotarget.10469

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