Sequestration of PRMT1 and Nd1-L mRNA into ALS-linked FUS mutant R521C-positive aggregates contributes to neurite degeneration upon oxidative stress

Mutations in fused in sarcoma (FUS), a DNA/RNA binding protein, are associated with familial amyotrophic lateral sclerosis (ALS). However, little is known about how ALS-causing mutations alter protein-protein and protein-RNA complexes and contribute to neurodegeneration. In this study, we identified...

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Detalles Bibliográficos
Autores principales: Jun, Mi-Hee, Ryu, Hyun-Hee, Jun, Yong-Woo, Liu, Tongtong, Li, Yan, Lim, Chae-Seok, Lee, Yong-Seok, Kaang, Bong-Kiun, Jang, Deok-Jin, Lee, Jin-A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240339/
https://www.ncbi.nlm.nih.gov/pubmed/28094300
http://dx.doi.org/10.1038/srep40474

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240339/
https://www.ncbi.nlm.nih.gov/pubmed/28094300
http://dx.doi.org/10.1038/srep40474

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