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Identification of positive selection in genes is greatly improved by using experimentally informed site-specific models
BACKGROUND: Sites of positive selection are identified by comparing observed evolutionary patterns to those expected under a null model for evolution in the absence of such selection. For protein-coding genes, the most common null model is that nonsynonymous and synonymous mutations fix at equal rat...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240389/ https://www.ncbi.nlm.nih.gov/pubmed/28095902 http://dx.doi.org/10.1186/s13062-016-0172-z |