New Insights into Cooperative Binding of Homeodomain Transcription Factors PREP1 and PBX1 to DNA

PREP1 and PBX1 are homeodomain (HD) transcription factors that play crucial roles in embryonic development. Here, we present the first biophysical characterization of a PREP1 HD, and the NMR spectroscopic study of its DNA binding pocket. The data show that residues flanking the HD participate in DNA...

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Detalles Bibliográficos
Autores principales: Zucchelli, Chiara, Ferrari, Elena, Blasi, Francesco, Musco, Giovanna, Bruckmann, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240567/
https://www.ncbi.nlm.nih.gov/pubmed/28094776
http://dx.doi.org/10.1038/srep40665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240567/
https://www.ncbi.nlm.nih.gov/pubmed/28094776
http://dx.doi.org/10.1038/srep40665

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