Fc-mediated activity of EGFR x c-Met bispecific antibody JNJ-61186372 enhanced killing of lung cancer cells

Epidermal growth factor receptor (EGFR) mutant non-small cell lung cancers acquire resistance to EGFR tyrosine kinase inhibitors through multiple mechanisms including c-Met receptor pathway activation. We generated a bispecific antibody targeting EGFR and c-Met (JNJ-61186372) demonstrating anti-tumo...

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Detalles Bibliográficos
Autores principales: Grugan, Katharine D., Dorn, Keri, Jarantow, Stephen W., Bushey, Barbara S., Pardinas, Jose R., Laquerre, Sylvie, Moores, Sheri L., Chiu, Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240640/
https://www.ncbi.nlm.nih.gov/pubmed/27786612
http://dx.doi.org/10.1080/19420862.2016.1249079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240640/
https://www.ncbi.nlm.nih.gov/pubmed/27786612
http://dx.doi.org/10.1080/19420862.2016.1249079

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