Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells

Lipotoxicity caused by saturated fatty acids (SFAs) induces tissue damage and inflammation in metabolic disorders. SCD1 (stearoyl-coenzyme A desaturase 1) converts SFAs to mono-unsaturated fatty acids (MUFAs) that are incorporated into triglycerides and stored in lipid droplets. SCD1 thus helps prot...

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Detalles Bibliográficos
Autores principales: Sinha, Rohit Anthony, Singh, Brijesh K., Zhou, Jin, Xie, Sherwin, Farah, Benjamin L., Lesmana, Ronny, Ohba, Kenji, Tripathi, Madhulika, Ghosh, Sujoy, Hollenberg, Anthony N., Yen, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Basic Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240836/
https://www.ncbi.nlm.nih.gov/pubmed/27846372
http://dx.doi.org/10.1080/15548627.2016.1235123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240836/
https://www.ncbi.nlm.nih.gov/pubmed/27846372
http://dx.doi.org/10.1080/15548627.2016.1235123

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