Anti-Prion Screening for Acridine, Dextran, and Tannic Acid using Real Time–Quaking Induced Conversion: A Comparison with PrP(Sc)-Infected Cell Screening

Prion propagation is mediated by the structural alteration of normal prion protein (PrP(C)) to generate pathogenic prion protein (PrP(Sc)). To date, compounds for the inhibition of prion propagation have mainly been screened using PrP(Sc)-infected cells. Real time–quaking-induced conversion (RT-QuIC...

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Detalles Bibliográficos
Autores principales: Hyeon, Jae Wook, Kim, Su Yeon, Lee, Sol Moe, Lee, Jeongmin, An, Seong Soo A., Lee, Myung Koo, Lee, Yeong Seon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240994/
https://www.ncbi.nlm.nih.gov/pubmed/28095474
http://dx.doi.org/10.1371/journal.pone.0170266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240994/
https://www.ncbi.nlm.nih.gov/pubmed/28095474
http://dx.doi.org/10.1371/journal.pone.0170266

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