Cargando…

Anti-Prion Screening for Acridine, Dextran, and Tannic Acid using Real Time–Quaking Induced Conversion: A Comparison with PrP(Sc)-Infected Cell Screening

Prion propagation is mediated by the structural alteration of normal prion protein (PrP(C)) to generate pathogenic prion protein (PrP(Sc)). To date, compounds for the inhibition of prion propagation have mainly been screened using PrP(Sc)-infected cells. Real time–quaking-induced conversion (RT-QuIC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hyeon, Jae Wook, Kim, Su Yeon, Lee, Sol Moe, Lee, Jeongmin, An, Seong Soo A., Lee, Myung Koo, Lee, Yeong Seon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5240994/ https://www.ncbi.nlm.nih.gov/pubmed/28095474 http://dx.doi.org/10.1371/journal.pone.0170266

Ejemplares similares

The Structure of PrP(Sc) Prions
por: Wille, Holger, et al.
Publicado: (2018)

Heterogeneity of Abnormal Prion Protein (PrP(Sc)) in Murine Scrapie Prions Determined by PrP(Sc)-Specific Monoclonal Antibodies
por: USHIKI-KAKU, Yuko, et al.
Publicado: (2013)

Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions
por: Miyazawa, Kohtaro, et al.
Publicado: (2015)

Exploration of the Main Sites for the Transformation of Normal Prion Protein (PrP(C)) into Pathogenic Prion Protein (PrP(sc))
por: Liu, Xi-Lin, et al.
Publicado: (2017)

PrP(Sc) formation and clearance as determinants of prion tropism
por: Shikiya, Ronald A., et al.
Publicado: (2017)

Sulfated Dextrans Enhance In Vitro Amplification of Bovine Spongiform Encephalopathy PrP(Sc) and Enable Ultrasensitive Detection of Bovine PrP(Sc)
por: Murayama, Yuichi, et al.
Publicado: (2010)

Anti-Prion Drug mPPIg5 Inhibits PrP(C) Conversion to PrP(Sc)
por: McCarthy, James M., et al.
Publicado: (2013)

PAD-Beads enrichment enhances detection of PrP(Sc) using real-time quaking-induced conversion
por: Hwang, Soyoun, et al.
Publicado: (2019)

The Octarepeat Region of the Prion Protein Is Conformationally Altered in PrP(Sc)
por: Yam, Alice Y., et al.
Publicado: (2010)

PrP(Sc)-Specific Antibodies with the Ability to Immunodetect Prion Oligomers
por: Tayebi, Mourad, et al.
Publicado: (2011)

Inflammatory response of microglia to prions is controlled by sialylation of PrP(Sc)
por: Srivastava, Saurabh, et al.
Publicado: (2018)

The prion 2018 round tables (I): the structure of PrP(Sc)
por: Baskakov, Ilia V., et al.
Publicado: (2019)

Establishing quantitative real-time quaking-induced conversion (qRT-QuIC) for highly sensitive detection and quantification of PrP(Sc) in prion-infected tissues
por: Shi, Song, et al.
Publicado: (2013)

Evaluation of the effect of various main elements on the PrP(Sc )detection by real-time quaking-induced conversion assay
por: Xiao, Kang, et al.
Publicado: (2018)

Small Protease Sensitive Oligomers of PrP(Sc) in Distinct Human Prions Determine Conversion Rate of PrP(C)
por: Kim, Chae, et al.
Publicado: (2012)

Glimepiride Reduces the Expression of PrP(C), Prevents PrP(Sc) Formation and Protects against Prion Mediated Neurotoxicity
por: Bate, Clive, et al.
Publicado: (2009)

A Camelid Anti-PrP Antibody Abrogates PrP(Sc) Replication in Prion-Permissive Neuroblastoma Cell Lines
por: Jones, Daryl Rhys, et al.
Publicado: (2010)

Identifying critical sites of PrP(c)-PrP(Sc) interaction in prion-infected cells by dominant-negative inhibition
por: Taguchi, Yuzuru, et al.
Publicado: (2013)

Heterogeneity of the Abnormal Prion Protein (PrP(Sc)) of the Chandler Scrapie Strain
por: Kasai, Kazuo, et al.
Publicado: (2013)

Glial activation in prion diseases is selectively triggered by neuronal PrP(Sc)
por: Lakkaraju, Asvin K. K., et al.
Publicado: (2022)

The First Evaluation of Proteinase K-Resistant Prion Protein (PrP(Sc)) in Korean Appendix Specimens
por: Won, Sae-Young, et al.
Publicado: (2022)

Analysis of Prion Strains by PrP(Sc) Profiling in Sporadic Creutzfeldt–Jakob Disease
por: Schoch, Gaby, et al.
Publicado: (2006)

PrP(Sc )spreading patterns in the brain of sheep linked to different prion types
por: Wemheuer, Wiebke M, et al.
Publicado: (2011)

Prion acute synaptotoxicity is largely driven by protease-resistant PrP(Sc) species
por: Foliaki, Simote Totauhelotu, et al.
Publicado: (2018)

Accumulation of Pathological Prion Protein PrP(Sc) in the Skin of Animals with Experimental and Natural Scrapie
por: Thomzig, Achim, et al.
Publicado: (2007)

How do PrP(Sc) Prions Spread between Host Species, and within Hosts?
por: Mabbott, Neil A.
Publicado: (2017)

Prion protein amino acid sequence influences formation of authentic synthetic PrP(Sc)
por: Block, Alyssa J., et al.
Publicado: (2023)

Propagation of PrP(Sc) in mice reveals impact of aggregate composition on prion disease pathogenesis
por: Chang, Sheng Chun, et al.
Publicado: (2023)

The N-Terminal Sequence of Prion Protein Consists an Epitope Specific to the Abnormal Isoform of Prion Protein (PrP(Sc))
por: Masujin, Kentaro, et al.
Publicado: (2013)

Sialylation of Prion Protein Controls the Rate of Prion Amplification, the Cross-Species Barrier, the Ratio of PrP(Sc) Glycoform and Prion Infectivity
por: Katorcha, Elizaveta, et al.
Publicado: (2014)

PK-sensitive PrP(Sc) Is Infectious and Shares Basic Structural Features with PK-resistant PrP(Sc)
por: Sajnani, Gustavo, et al.
Publicado: (2012)

Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP
por: Sakudo, Akikazu, et al.
Publicado: (2015)

Disulfide-crosslink scanning reveals prion–induced conformational changes and prion strain–specific structures of the pathological prion protein PrP(Sc)
por: Taguchi, Yuzuru, et al.
Publicado: (2018)

Recombinant PrP(Sc) shares structural features with brain-derived PrP(Sc): Insights from limited proteolysis
por: Sevillano, Alejandro M., et al.
Publicado: (2018)

Mammalian prion propagation in PrP transgenic Drosophila
por: Thackray, Alana M, et al.
Publicado: (2018)

Kosmotropic Anions Promote Conversion of Recombinant Prion Protein into a PrP(Sc)-Like Misfolded Form
por: Diaz-Espinoza, Rodrigo, et al.
Publicado: (2012)

Detection of Pathognomonic Biomarker PrP(Sc) and the Contribution of Cell Free-Amplification Techniques to the Diagnosis of Prion Diseases
por: Eraña, Hasier, et al.
Publicado: (2020)

Down-Regulation of Shadoo in Prion Infections Traces a Pre-Clinical Event Inversely Related to PrP(Sc) Accumulation
por: Westaway, David, et al.
Publicado: (2011)

Species and Strain Glycosylation Patterns of PrP(Sc)
por: Xanthopoulos, Konstantinos, et al.
Publicado: (2009)

The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro
por: Honda, Ryo P., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_sjk9q97mvhr1f0btkssfjv83oc