CRL4(WDR1) Controls Polo-like Kinase Protein Abundance to Promote Bilobe Duplication, Basal Body Segregation and Flagellum Attachment in Trypanosoma brucei

The Polo-like kinase homolog in Trypanosoma brucei, TbPLK, plays essential roles in basal body segregation, flagellum attachment and cytokinesis. The level of TbPLK protein is tightly controlled, but the underlying mechanism remains elusive. Here, we report a Cullin-RING ubiquitin ligase composed of...

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Detalles Bibliográficos
Autores principales: Hu, Huiqing, Zhou, Qing, Han, Xianxian, Li, Ziyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241021/
https://www.ncbi.nlm.nih.gov/pubmed/28052114
http://dx.doi.org/10.1371/journal.ppat.1006146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241021/
https://www.ncbi.nlm.nih.gov/pubmed/28052114
http://dx.doi.org/10.1371/journal.ppat.1006146

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