MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and pro-survival factors, the most important of which is the NAD(+) biosynthetic enzyme NMNAT2 that inhibits activation of the SARM1 pathway. Here we inves...

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Detalles Bibliográficos
Autores principales: Walker, Lauren J, Summers, Daniel W, Sasaki, Yo, Brace, EJ, Milbrandt, Jeffrey, DiAntonio, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241118/
https://www.ncbi.nlm.nih.gov/pubmed/28095293
http://dx.doi.org/10.7554/eLife.22540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241118/
https://www.ncbi.nlm.nih.gov/pubmed/28095293
http://dx.doi.org/10.7554/eLife.22540

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